What is the 6-base genome?
The 6-base genome ads 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) to the traditional nucleobases of adenine (A), cytosine (C), guanine (G), and thymine (T).
The 6-base genome ads 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) to the traditional nucleobases of adenine (A), cytosine (C), guanine (G), and thymine (T).
We are delighted to present BaseSpace Sequence Hub data for duet multiomics solution +modC.
RNA sequencing (RNA-seq) has become immensely popular and indispensable in modern biological research. We look at the considerations and challenges of this technology.
Novel solution – duet evoC – distinguishes 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) revealing unprecedented insights into current and future states of disease using one 5ng DNA sample
Liquid biopsy for profiling of cell free DNA (cfDNA) in blood holds huge promise to transform how we experience and manage cancer by early detection and identification of residual disease and subtype. However, a standard blood draw yields an average of only 10 ng of cfDNA, of which DNA derived from the tumour is a small minority.
DNA comprises molecular information stored in genetic and epigenetic bases, both of which are vital to our understanding of biology. In human genomes, an epigenetic modification at the fifth carbon of cytosines bases comprises one fundamental pathway by which genes can be silenced or activated.
DNA comprises molecular information stored in genetic and epigenetic bases, both of which are vital to our understanding of biology. The interplay between genetics and the DNA epigenome orchestrates complex biological phenomena as diverse as cell fate, ageing, the response to environmental stimuli, and disease pathogenesis.
Epigenetics, a captivating field of study, has revolutionised our understanding of gene regulation.
A Q&A with Peter Fromen, CEO of biomodal, emphasising the potential applications of their technology, particularly in oncology, liquid biopsy, aging, and neurodegenerative disorders.
DNA stores multimodal information through a process known as DNA methylation and it plays a crucial role in gene expression and regulation.